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The “Francesca’s Cells” Research Project

Molecular characterization of Acute Myeloid Leukemia

“ Le Cellule di Francesca project is in full swing here in the laboratories of the Regina Elena Institute in Rome. The first phases of our work are aimed at the production of a cell line that carries the same mutations found in the leukemia diagnosed in Francesca. For this purpose, a leukemia cell line similar to Francesca’s has been acquired and we are establishing the most effective methods to manipulate and analyze it. A plasmid, a “packet” of DNA, containing the exact mutations that have been identified in Francesca’s genes, was also commissioned to a specialized company; thanks to it, we will be able to obtain an experimental model in the cells with which to reconstruct the molecular pathological picture of this extremely aggressive cancer. In the future, the cells thus obtained can also be compared with the original cells, which will help to highlight any particularities of the disease.
A second line of the project is based on the work initiated by the late Prof. Francesco LoCoco. Through the Whole Exome Sequencing procedure, a DNA library of Francesca and her parents was created, which allows the comparative study of the genes involved in the disease. Comparing these data also with those obtained in 2018 by Prof. Robin Foà of the Policlinico Umberto I, the analysis we started could highlight other possible mutations responsible for Francesca’s disease that could, in the future, be used to diagnose these fulminant forms of Acute Myeloid Leukemia .
Dr. Gabriele Loiudice, Rome 02/11/2020

Gabriele Loiudice is the winner of the scholarship for the project “Identification and study of the impact of genetic variants of susceptibility in adolescent acute myeloid leukemia (AML)”, Maurizio Fanciulli, Principal Investigator. Click on Gabriele’s name for his C.v.

The bursary announcement and results are available on the IFO website.

Public call for scholarship n. 18 of 12.06.2020 in .pdf format or in .doc format
Scholarship N. 18/2020 was awarded with resolution 922 of 25.08.2020

The project stems from a collaboration started in November 2017 between the IRCCS Regina Elena National Cancer Institute of Rome – where the cells are hosted – by Prof. Gennaro Ciliberto Scientific Director and Maurizio Fanciulli PhD, of the Department of Research, Diagnosis and Innovative Technologies, Traslational Research Area and the UOC Enhanced Diagnostic Oncoematologica of the University of Rome Tor Vergata by the late Prof. Francesco Lo Coco and Prof. Maria Teresa Voso, Director.

The Research Project “Francesca‘s Cells” – a molecular characterisation of acute leukaemia – was announced for the first time in this brochure created by the late Mario Spadetta and distributed at the Treasure hunt “La Nave di Nana” on Serapo Beach, Gaeta, on July 7th, 2018.

What we do

The fourth edition of Francesca Martini Prize to the Best Poster in Cancer Research was won by Emanuele Monteleone for his poster “STAT3-dependent pluripotency control via the stam-cells specific long non-coding RNA LincS1“. Emanuele graduated from the University of Turin. Here is his C.v.

The Francesca Martini Prize stems from a collaboration between NAnA onlus and SIBBM, the Italian Society of Biophysics and Molecular Biology. An International Jury of Scientists choses the best poster among those exhibited at the Annual SIBBM Seminar.

The 2019 “Frontiers in Molecular Biology” SIBBM Seminar took place from 11 to 13 June in Bologna.

Francesca Martini Prize to the Best Poster in Cancer Research

WINNERS

2016 Stefano Amente of the University Federico II of Naples for the poster “High-resolution genome profiles of 8-oxodeoxyguanine, γH2AX and NBS1 reveal their co-association at transcribed long genes“. For more information, click here.
2017 Davide Cassani for his poster Cryo electron tomography of actomyosin cortex in isolated blebs“. Here is his C.v.
2018 Valeria Rosato for her poster “miR-27a-3p is a master regulator of metabolic reprogramming in colorectal cancer“. Here is her C.v.
What we do


NAnA Music – Scholarships for young rock musicians stems from an idea of NAnA Onlus and Frontiers Music.
The aim is to offer an alternative path to young students from disadvantaged backgrounds from the age 15 to 18.
Winners register to the Corso PRO at SONUS FACTORY – Music Performance Institute – Rome and  obtain a certificate from Rockschool Uk – Europe’s No.1 Rock music exam board.
Fellowships are for one year renewable up to a maximum of 3. The final Diploma is recognised as level 3 by the European Union standards.
Young musicians may chose among Guitar – Bass – Drums – Vocals – Piano.
E-mail us if you want to audition for NAnA Music.

Bando Nana Music 2019

Highlight, What we do

The fourth edition of La Nave di NAnA is now completed.

This year, thanks to the presence of many old and new friends, the fundraising reached the record of € 1500!

THANKS to everyone!

 

La Nave di Nana